Catalogue number: C377870
Chemical name: (2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone
Synonyms: GDC-0068; Ipatasertib; RG 7440
CAS Number: 1001264-89-6
Possible CAS #: NA
Molecular form.: C₂₄H₃₂ClN₅O₂
Appearance: Peach Solid
Melting Point: >106°C (dec.)
Mol. Weight: 458
Storage: Hygroscopic, Refrigerator, under inert atmosphere
Solubility: Acetonitriele (Slightly), DMSO (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: (2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone is a highly selective AKT inhibitor targeting Akt1, Akt2 and Akt3. Studies have shown its use in combination with vemurafenib (V118500), have demonstrated therapeutic value in the treatment of hyperproliferative disorders such as cancer.
Dangerous Goods Info: NA
Peer Review Product Citations:

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