2-Chloro-5-nitro-N-4-pyridinylbenzamide
| Catalogue number: | C374760 |
| Chemical name: | 2-Chloro-5-nitro-N-4-pyridinylbenzamide |
| Synonyms: | T0070907 |
| Impurity: | |
| CAS Number: | 313516-66-4 |
| Possible CAS #: | NA |
| Molecular form.: | C₁₂H₈ClN₃O₃ |
| Appearance: | Light Orange Solid |
| Melting Point: | >184°C (dec.) |
| Mol. Weight: | 277.66 |
| Storage: | Refrigerator |
| Solubility: | DMSO (Slightly), Methanol (Slightly) |
| Stability: | No Data Available |
| Category: | Inhibitors |
| Boiling Point: | No Data Available |
| Applications: | A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1 nM. Displays >800-fold greater selectivity for PPARγ over PPARα and PPARδ (Ki = 0.85 µM and 1.8 µM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARγ and coactivator-derived peptides, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARγ2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding domain. |
| Dangerous Goods Info: | NA |
| References: | |
| Peer Review Product Citations: | |
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