Catalogue number: C374760
Chemical name: 2-Chloro-5-nitro-N-4-pyridinylbenzamide
Synonyms: T0070907
CAS Number: 313516-66-4
Alternate CAS #: NA
Molecular form.: C₁₂H₈ClN₃O₃
Appearance: Light Orange Solid
Melting Point: >184°C (dec.)
Mol. Weight: 277.66
Storage: Refrigerator
Solubility: DMSO (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Inhibitors
Boiling Point: No Data Available
Applications: A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1 nM. Displays >800-fold greater selectivity for PPARγ over PPARα and PPARδ (Ki = 0.85 µM and 1.8 µM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARγ and coactivator-derived peptides, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARγ2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding domain.
Dangerous Goods Info: NA

All Products are stable to be shipped at room temperature, unless otherwise specified.
Keywords: Buy 313516-66-4 | Purchase 313516-66-4 | Order 313516-66-4 | 313516-66-4 supplier | 313516-66-4 manufacturer | 313516-66-4 distributor | 313516-66-4 cost

Order Product

  Pack size Price(USD)
1mg $45.00
10mg $65.00
50mg $265.00
  Pack size Price(USD)
5mg $50.00
25mg $140.00
100mg $495.00

Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   Pending QC

Search Products:

Enter Catalogue #, CAS # , Chemical Name or Mol Formula:

Bulk Orders

If you require bulk orders or quantities you don't see listed, please click here

Translate »