C281103 Chemical Structure

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C281103

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Product Description

Catalogue NumberC281103
Chemical Name(±)-Cetirizine-d4 Dihydrochloride
Synonyms[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy-d4]acetic Acid Dihydrochloride; Alercet-d4; Alerid-d4; Alerlisin-d4; Cesta-d4; Cetiriz-d4; Cetirizine-d4 Dihydrochloride; Cetirizine-d4 Hydrochloride; Cetrak-d4; Cetrine-d4; Cetrizet-d4; Cistamine-d4; Epirizine-d4; Formistin-d4; Histazine-d4; Histazine-1-d4; Nosemin-d4; P 071-d4; Reactine-d4; Riztec-d4; Ryzen-d4; Sancotec-d4; Selitex-d4; Tomazine-d4; Triz-d4; UCB-P 071-d4; Virlix-d4; Zeran-d4; Zirtec-d4; Zirtek-d4; Zirtin-d4; Zyrlex-d4; Zyrtec-d4; Zyrzine-d4
CAS Number1219803-84-5
Alternate CAS #Unlabelled: 83881-52-1
Molecular FormulaC₂₁H₂₁D₄ClN₂O₃ • 2HCl
AppearanceWhite to Off-White Solid
Melting Point>202ºC (dec.)
Molecular Weight392.92 + 2(36.46)
StorageHygroscopic, -20°C Freezer, Under inert atmosphere
SolubilityDMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)
StabilityHygroscopic
Category Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
Applications(±)-Cetirizine-d4 Dihydrochloride is the labeled analogue of Cetirizine Dihydrochloride (C281100), a nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic.
ReferencesDe Vos, C., et al.: Ann. Allergy, 59, 278 (1987); Juhlin, L., et al.: J. Allergy Clin. Immunol., 80, 599 (1987); Fadel, R., et al.: Clin. Allergy, 17, 373 (1987); Gengo, F.M., et al.: Clin. Pharmacol. Ther., 42, 265 (1987)