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Pack Size | Quantity | Price (USD) | Sub Total |
---|---|---|---|
5mg | $ 100.00 | 0.0 | |
10mg | $ 135.00 | 0.0 | |
25mg | $ 305.00 | 0.0 | |
50mg | $ 580.00 | 0.0 | |
Exact Weight Packaging | $ 145.00 | 0.0 | |
Total | $ 0.0 |
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C228800
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Product Description
Catalogue Number | C228800 |
Chemical Name | CDPPB |
Synonyms | 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide |
CAS Number | 781652-57-1 |
Molecular Formula | C₂₃H₁₆N₄O |
Appearance | White to Off-White Solid |
Melting Point | 210-212°C |
Molecular Weight | 364.4 |
Storage | 4°C |
Solubility | DMSO (Slightly), Ethyl Acetate (Slightly) |
Category | Research Tools; Pharmaceutical/API Drug Impurities/Metabolites; |
Applications | CDPPB is a glutamate metabotropic (mGluR5) positive allosteric modulator, used in the treatment of Phelan-McDermid syndrome caused by 22qI3 deletion. Studies have shown that CDPPB suppresses the increase of LDH release and caspase-3 activation induced by traumatic neuronal injury. |
References | Chen, T. et al.: Neurochem. Res., 37, 983 (2012); Rodriguez, A. et al.: Bioorg. Med. Chem. Lett., 22, 7388 (2012); Gregory, K. et al.: Mol. Pharmacol., 82, 860 (2012) |