C228100 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
5mg
$ 50.000.0
10mg
$ 70.000.0
25mg
$ 95.000.0
50mg
$ 185.000.0
100mg
$ 360.000.0
Exact Weight Packaging
$ 95.000.0
Total$ 0.0
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C228100

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Product Description

Catalogue NumberC228100
Chemical NameCDDO Methyl Ester
Synonyms2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid Methyl Ester; Bardoxolone Methyl; CDDO-Me; Methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate; NSC 713200; RTA 402;
CAS Number218600-53-4
Molecular FormulaC₃₂H₄₃NO₄
AppearanceWhite to Light Brown Solid
Melting Point215-223°C
Molecular Weight505.69
StorageRefrigerator
SolubilityChloroform (Slightly), Methanol (Slightly)
Category Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsCDDO Methyl Ester is a synthetic triterpenoid that inhibits IκBα kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor κB-regulated gene products in human leukemic cells. CDDO Methyl Ester is a novel therapeutic agent in the treatment of acute myeloid leukemia and in the treatment of pancreatic cancer as well as other forms of cancer.
ReferencesShishodia, S. et al.: Clin. Cancer Res., 12, 1828 (2006); Konopleva, M. et al.: Leukemia, 19, 1350 (2005); Deeb, D. et al.: Cancers, 2, 1779 (2010); Gao, X. et al.: J. Exp. Therap. Oncol., 9, 119 (2011);