Aromatics, Heterocycles, Indole Deribatives, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals,
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CCT036477 is an inhibitor of Wnt signaling. Studies show that CCT036477 does not alter ?-catenin levels but blocks transcription at the ?-catenin level. CCT036477 inhibited growth in several cancer cell lines and showed clear activity in vivo, blocking development of Zebrafish and Xenopus embryos and expression of Wnt target genes.