Cabozantinib L-Malate Salt


Catalogue number: C051500
Chemical name: Cabozantinib L-Malate Salt
Synonyms: N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N’-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (2S)-2-Hydroxybutanedioic Acid; Cabozantinib S-Malate; XL 184;
Impurity:
CAS Number: 1140909-48-3
Alternate CAS #: 849217-68-1-free base
Molecular form.: C₃₂H₃₀FN₃O₁₀
Appearance: White to Off-White Solid
Melting Point: 166-169°C
Mol. Weight: 635.59
Storage: Refrigerator
Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
Stability: No Data Available
Category: Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Protein Kinase Inhibitors and Activators,
Boiling Point: No Data Available
Applications: Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis.
Dangerous Goods Info: NA
References:

All Products are stable to be shipped at room temperature, unless otherwise specified.
MSDS: C051500.pdf
Product Rating
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50mg $225.00
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Exact Weight Packaging ($75(USD) / Vial)
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Inventory Status:   In Stock




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