B942750 Chemical Structure

All Products are stable to be shipped at room temperature, unless otherwise specified.
Pack SizeQuantityPrice (USD)Sub Total
5mg
$ 60.000.0
10mg
$ 100.000.0
25mg
$ 220.000.0
50mg
$ 430.000.0
100mg
$ 835.000.0
250mg
$ 1850.000.0
Exact Weight Packaging
$ 95.000.0
Total$ 0.0
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B942750

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Product Description

Catalogue NumberB942750
Chemical Name((O,O')-tert-Butyldimethylsilyl) Seco-ezetimibe
Synonyms(2R,5S)-5-((tert-Butyldimethylsilyl)oxy)-2-((S)-(4-((tert-butyldimethylsilyl)oxy)phenyl)((4-fluorophenyl)amino)methyl)-5-(4-fluorophenyl)pentan-1-ol
Molecular FormulaC₃₆H₅₃F₂NO₃Si₂
AppearanceWhite Solid
Molecular Weight641.98
SolubilityDichloromethane, Ethyl Acetate
Category Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications((O,O')-tert-Butyldimethylsilyl) Seco-ezetimibe is an intermediate in the synthesis of 4’-O-Benzyloxy Ezetimibe Diol Impurity (B287130). 4’-O-Benzyloxy Ezetimibe Diol Impurity is an impurity of Ezetimibe (E975000); an antihyperlipoproteinemic and cholesterol absorption inhibitor.
ReferencesGajjar, A.K., et al.: Open Conf. Proc. J., 2, 108 (2011); van Heek, M., et al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., et al.: Brit. J. Pharmacol., 129, 1748 (2000)