B942748 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
10mg
$ 60.000.0
25mg
$ 130.000.0
50mg
$ 235.000.0
100mg
$ 450.000.0
250mg
$ 1100.000.0
500mg
$ 1970.000.0
Exact Weight Packaging
$ 95.000.0
Total$ 0.0
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B942748

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Product Description

Catalogue NumberB942748
Chemical Name((O,O')-tert-Butyldimethylsilyl) Ezetimibe
Synonyms(3R,4S)-3-((S)-3-((tert-Butyldimethylsilyl)oxy)-3-(4-fluorophenyl)propyl)-4-(4-((tert-butyldimethylsilyl)oxy)phenyl)-1-(4-fluorophenyl)azetidin-2-one
Molecular FormulaC₃₆H₄₉F₂NO₃Si₂
AppearanceClear Oil
Molecular Weight637.95
SolubilityDichloromethane, Ethyl Acetate
Category Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications((O,O')-tert-Butyldimethylsilyl) Ezetimibe is an intermediate in the synthesis of 4’-O-Benzyloxy Ezetimibe Diol Impurity (B287130). 4’-O-Benzyloxy Ezetimibe Diol Impurity is an impurity of Ezetimibe (E975000); an antihyperlipoproteinemic and cholesterol absorption inhibitor.
ReferencesGajjar, A.K., et al.: Open Conf. Proc. J., 2, 108 (2011); van Heek, M., et al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., et al.: Brit. J. Pharmacol., 129, 1748 (2000)