B686025 Chemical Structure

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  • Ships On : 2/10/2022
B686025

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Product Description

Catalogue NumberB686025
Chemical Name3-Bromo-2-fluorobenzoic Acid
Synonyms2-Fluoro-3-bromobenzoic Acid; 3-Bromo-2-fluorobenzenecarboxylic Acid
CAS Number161957-56-8
Molecular FormulaC₇H₄BrFO₂
Molecular Weight219.01
Category Building Blocks; Miscellaneous;
Applications3-Bromo-2-fluorobenzoic acid is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 3-Bromo-2-fluorobenzoic acid is also used as a reagent to prepare Alkynlphenoxyacetic acid receptor agonists, compounds that can be potentially used for the treatment of allergic inflammatory diseases (such as allergic rhinitis).
ReferencesBrose, M., et al.: Cancer Res., 62, 6997 (2002); Crosignani, S., et al.: J. Med. Chem., 54, 7299 (2011); Rheault, T., et al.: ACS Med. Chem. Lett., 4, 358 (2013)