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|Pack Size||Quantity||Price (USD)||Sub Total|
|Exact Weight Packaging||$ 95.00||0.0|
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- Ships On : 2/10/2022
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|Chemical Name||3-Bromo-2-fluorobenzoic Acid|
|Synonyms||2-Fluoro-3-bromobenzoic Acid; 3-Bromo-2-fluorobenzenecarboxylic Acid|
|Category||Building Blocks; Miscellaneous;|
|Applications||3-Bromo-2-fluorobenzoic acid is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 3-Bromo-2-fluorobenzoic acid is also used as a reagent to prepare Alkynlphenoxyacetic acid receptor agonists, compounds that can be potentially used for the treatment of allergic inflammatory diseases (such as allergic rhinitis).|
|References||Brose, M., et al.: Cancer Res., 62, 6997 (2002); Crosignani, S., et al.: J. Med. Chem., 54, 7299 (2011); Rheault, T., et al.: ACS Med. Chem. Lett., 4, 358 (2013)|