B676645 Chemical Structure

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B676645

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Product Description

Catalogue NumberB676645
Chemical Name(+)-cis-anti-N2-BPDE-dG
Synonyms[7R-(7α,8β,9β,10β)]-2'-Deoxy-N-(7,8,9,10-tetrahydro-7,8,9-trihydroxybenzo[a]pyren-10-yl)-Guanosine; Benzo[a]pyrene, guanosine deriv.; (+)-cis-anti-7,8,9-Trihydroxy-10-(2'-deoxyguanosin-2-yl)benzo[a]pyrene
CAS Number66141-82-0
Molecular FormulaC30H27N5O7
Molecular Weight569.56
Category Standards; Pharmaceutical/API Drug Impurities/Metabolites; Environmental Standards, Mutagens and Metabolites;
Applications(+)-cis-anti-N2-BPDE-dG is used in the study of carcinogen-DNA adducts and their role in affecting eukaryotic DNA methyltransferases. Cluster-type DNA damage is often seen in DNA and is usually skipped by base excision repair.
ReferencesSkosareva, L. et al.: DNA Repair., 11, 367 (2012); Minero, A. et al.: FEBS J. et al.: 279, 3965 (2012);