B676642 Chemical Structure

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B676642

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Product Description

Catalogue NumberB676642
Chemical Name(+)-trans-anti-BPDE-N2-dG-d8
Synonyms(+)-trans-anti-Benzo[a]pyrene-dG-d8; 10S(+)-trans-anti-[Py]-N2-dG-d8; [7R-(7α,8β,9β,10α)]-2'-deoxy-N-(7,8,9,10-tetrahydro-7,8,9-trihydroxybenzo[a]pyren-10-yl)guanosine-d8; Benzo[a]pyrene guanosine deriv.-d8; (+)-r-7,t-8-Dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene-dG-d8; (+)-trans-anti-7,8,9-Trihydroxy-10-(2'-deoxyguanosin-2-yl)benzo[a]pyrene-d8
Alternate CAS #Unlabelled: 65437-20-9
Molecular FormulaC₃₀H₁₉D₈N₅O₇
Molecular Weight577.61
Category Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites; Environmental Standards, Mutagens and Metabolites;
ApplicationsIsotope labelled (+)-trans-anti-BPDE-N2-dG is used in the study of carcinogen-DNA adducts and their role in affecting eukaryotic DNA methyltransferases. Cluster-type DNA damage is often seen in DNA and is usually skipped by base excision repair. Also, as a common concern due to tobacco smoke, this compound used to obtain a better understanding of the effects of carcinnogen-DNA adducts.
ReferencesSkosareva, L. et al.: DNA Repair., 11, 367 (2012); Minero, A. et al.: FEBS J. et al.: 279, 3965 (2012); Strasser, A. et al.: Cancer Epidemiol. Biomark. Prev., 22, 382 (2013);