B676637 Chemical Structure

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5mg
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B676637

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Product Description

Catalogue NumberB676637
Chemical Name(-)-cis-anti-N2-BPDE-dG-d8
Synonyms[7S-(7α,8β,9β,10β)]-2'-Deoxy-N-(7,8,9,10-tetrahydro-7,8,9-trihydroxybenzo[a]pyren-10-yl)guanosine-d8; Benzo[a]pyrene Guanosine deriv.-d8; (-)-cis-anti-7,8,9-Trihydroxy-10-(2'-deoxyguanosin-2-yl)benzo[a]pyrene-d8
Alternate CAS #Unlabelled: 66113-73-3
Molecular FormulaC30H19D8N5O7
Molecular Weight577.61
Category Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites; Environmental Standards, Mutagens and Metabolites;
ApplicationsIsotope labelled (-)-cis-anti-N2-BPDE-dG-d8 is used in the study of carcinogen-DNA adducts and their role in affecting eukaryotic DNA methyltransferases. Cluster-type DNA damage is often seen in DNA and is usually skipped by base excision repair.
ReferencesSkosareva, L. et al.: DNA Repair., 11, 367 (2012); Minero, A. et al.: FEBS J. et al.: 279, 3965 (2012); Hoare, S. et al.: Biochem., 39, 12252 (2000);