B592490 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
5mg
$ 80.000.0
10mg
$ 110.000.0
25mg
$ 255.000.0
50mg
$ 495.000.0
100mg
$ 955.000.0
Exact Weight Packaging
$ 95.000.0
Total$ 0.0
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B592490

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Product Description

Catalogue NumberB592490
Chemical Name(+/-)-Blebbistatin
Synonyms1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one; (+/-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one; Blebbistatin;
CAS Number674289-55-5
Molecular FormulaC₁₈H₁₆N₂O₂
AppearanceLight Yellow to Yellow Solid
Melting Point>180°C (dec.)
Molecular Weight292.33
Storage-20°C Freezer
SolubilityChloroform (Slightly, Sonicated), Ethyl Acetate (Slightly)
Category Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsBlebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100µM. (±)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one Selective inhibitor of nonmuscle myosin II; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.
ReferencesStraight, A.F., et al.: Science, 299, 1743 (2003), Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun., 313, 992 (2004), Kovacs, M., et al.: J. Biol. Chem., 279, 34 35557 (2004)