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|Pack Size||Quantity||Price (USD)||Sub Total|
|Exact Weight Packaging||$ 95.00||0.0|
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|Synonyms||1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one; (+/-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one; Blebbistatin;|
|Appearance||Light Yellow to Yellow Solid|
|Melting Point||>180°C (dec.)|
|Solubility||Chloroform (Slightly, Sonicated), Ethyl Acetate (Slightly)|
|Category||Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;|
|Applications||Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100µM.(±)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-oneSelective inhibitor of nonmuscle myosin II; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.|
|References||Straight, A.F., et al.: Science, 299, 1743 (2003), Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun., 313, 992 (2004), Kovacs, M., et al.: J. Biol. Chem., 279, 34 35557 (2004)|