Catalogue number: B591700
Chemical name: Bizelesin
Synonyms: N,N’-Bis[2-[[(1S)-1-(chloromethyl)-1,6-dihydro-5-hydroxy-8-methylbenzo[1,2-b:4,3-b’]dipyrrol-3(2H)-yl]carbonyl]-1H-indol-5-yl]urea; (8S,8’S)-6,6’-[Carbonylbis(imino-1H- indole-5,2-diylcarbonyl)]bis[8-(chloromethyl)-3,6,7,8-tetrahydro-1-methylbenzo[1,2-b:4,3-b’]dipyrrol-4-ol; NSC 615291; U 77779;
CAS Number: 129655-21-6
Possible CAS #: NA
Molecular form.: C₄₃H₃₆Cl₂N₈O₅
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 815.7
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Chiral Reagents, Indole Derivatives, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: As members of the cyclopropylpyrroloindole family, Adozelesin and Bizelesin cause genomic DNA lesions by alkylating DNA. Adozelesin induces single-strand DNA lesions, whereas Bizelesin induces both single-strand lesions and double-strand DNA cross-links. Thus, despite similar abilities to alkylate DNA, the chemotherapeutic agents Adozelesin and Bizelesin caused a decrease in HCT116 tumor cell proliferation by different pathways (i.e., Adozelesin induced apoptosis, and Bizelesin induced senescence).
Dangerous Goods Info: NA
Peer Review Product Citations:
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