Catalogue Number: B415890
Chemical Name: 4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole
Synonyms: 4-[(1E,3S,5Z,10S)-3,11-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,6,10-trimethyl-1,5-undecadien-1-yl]-2-methyl-thiazole;
CAS Number: 210690-85-0
Molecular Formula: C₃₀H₅₇NO₂SSi₂
Appearance: Colourless Oil
Molecular Weight: 552.02
Solubility: Chloroform, Dichloromethane, Ethanol, Ethyl Acetate, Methanol, Toluene
Category: Chiral Reagents
Applications: An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells’ microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.

All Products are stable to be shipped at room temperature, unless otherwise specified.
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  Pack size Price(USD)
100mg $75.00
500mg $225.00
2g $800.00
  Pack size Price(USD)
250mg $125.00
1g $425.00
2.5g $1000.00

Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   Pending QC

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