B330242 Chemical Structure

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Product Description

Catalogue NumberB330242
Chemical NameBetulin-d3
SynonymsLup-20(29)-ene-3β,28-diol-d3; Lup-20(30)-ene-3β,28-diol-d3; (+)-Betulin-d3; 3,28-Dihydroxy-lupeol-d3; 3β,28-Dihydroxylup-20(29)-ene-d3; Betulin-d3; Betuline-d3; Betulinic Alcohol-d3; Betulinol-d3; Betulol-d3; NSC 4644-d3; Trochol-d3
Alternate CAS #Unlabelled: 473-98-3
Molecular FormulaC₃₀H₄₇D₃O₂
AppearanceWhite Solid
Melting Point239-241°C
Molecular Weight445.74
StorageHygroscopic, -20°C Freezer, Under inert atmosphere
SolubilityChloroform(Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
Category Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsBetulin-d3 is the isotope labelled analog of Betulin (B330240); a derivative of Betulinic Acid (B330250) which is a compound used in the treatment of cancer and HIV disease. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity
ReferencesCichewicz, R. et al.: Med. Res. Rev., 24, 90 (2003); Pisha, E. et al.: Nat. Med., 1, 1046 (1995); Fulda, S. et al.: Cancer Res., 57, 4956 (1997); Kashiwada, Y. et al.: J. Med. Chem., 39, 1016 (1996); Genet, C. et al.: J. Med. Chem., 53, 178 (2010)