B330240 Chemical Structure

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B330240

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Product Description

Catalogue NumberB330240
Chemical NameBetulin
SynonymsLup-20(29)-ene-3β,28-diol; Lup-20(30)-ene-3β,28-diol; 3aH-Cyclopenta[a]chrysene, lup-20(29)-ene-3,28-diol deriv.; (+)-Betulin; 3,28-Dihydroxy-lupeol; 3β,28-Dihydroxylup-20(29)-ene; Betulin; Betuline; Betulinic alcohol; Betulinol; Betulol; NSC 4644; Trochol
CAS Number473-98-3
Molecular FormulaC₃₀H₅₀O₂
AppearancePale Brown to Beige Solid
Melting Point>250°C (dec.)
Molecular Weight442.72
StorageHygroscopic, -20°C Freezer, Under inert atmosphere
SolubilityChloroform (Slightly), Methanol (Slightly, Heated)
StabilityHygroscopic
Category Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsBetulin is a derivative of Betulinic Acid (B330250), used in the treatment of cancer and HIV disease. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity
ReferencesCichewicz, R. et al.: Med. Res. Rev., 24, 90 (2003); Pisha, E. et al.: Nat. Med., 1, 1046 (1995); Fulda, S. et al.: Cancer Res., 57, 4956 (1997); Kashiwada, Y. et al.: J. Med. Chem., 39, 1016 (1996); Genet, C. et al.: J. Med. Chem., 53, 178 (2010);