TRC | Details of CAS = 473-98-3, ChemicalName = Betulin, synonym = Lup-20(29)-ene-3β,28-diol; Lup-20(30)-ene-3β,28-diol; 3aH-Cyclopenta[a]chrysene, lup-20(29)-ene-3,28-diol deriv.; (+)-Betulin; 3,28-Dihydroxy-lupeol; 3β,28-Dihydroxylup-20(29)-ene; Betulin; Betuline; Betulinic alcohol; Betulinol; Betulol; NSC 4644; Trochol, MolFormula = C₃₀H₅₀O₂

Catalogue number:	B330240
Chemical name:	Betulin
Synonyms:	Lup-20(29)-ene-3β,28-diol; Lup-20(30)-ene-3β,28-diol; 3aH-Cyclopenta[a]chrysene, lup-20(29)-ene-3,28-diol deriv.; (+)-Betulin; 3,28-Dihydroxy-lupeol; 3β,28-Dihydroxylup-20(29)-ene; Betulin; Betuline; Betulinic alcohol; Betulinol; Betulol; NSC 4644; Trochol
Impurity:
CAS Number:	473-98-3
Alternate CAS #:	NA
Molecular form.:	C₃₀H₅₀O₂
Appearance:	Beige Solid
Melting Point:	>250°C (dec.)
Mol. Weight:	442.72
Storage:	Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility:	Chloroform (Slightly), Methanol (Slightly)
Stability:	No Data Available
Category:	Agonist, Anti-virals, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point:	No Data Available
Applications:	Betulin is a derivative of Betulinic Acid (B330250), used in the treatment of cancer and HIV disease. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity
Dangerous Goods Info:	NA
References:	Cichewicz, R. et al.: Med. Res. Rev., 24, 90 (2003); Pisha, E. et al.: Nat. Med., 1, 1046 (1995); Fulda, S. et al.: Cancer Res., 57, 4956 (1997); Kashiwada, Y. et al.: J. Med. Chem., 39, 1016 (1996); Genet, C. et al.: J. Med. Chem., 53, 178 (2010);

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