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| Pack Size | Quantity | Price (USD) | Sub Total |
|---|---|---|---|
| 1mg | $ 58.00 | 0.0 | |
| 5mg | $ 64.00 | 0.0 | |
| 10mg | $ 69.00 | 0.0 | |
| Exact Weight Packaging | $ 145.00 | 0.0 | |
| Total | $ 0.0 | ||
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B285725
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Product Description
| Catalogue Number | B285725 |
| Chemical Name | 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione |
| Synonyms | GSK-3ß Inhibitor I, TDZD-8 |
| CAS Number | 327036-89-5 |
| Molecular Formula | C₁₀H₁₀N₂O₂S |
| Appearance | White Solid |
| Melting Point | 60-61°C |
| Molecular Weight | 222.26 |
| Storage | -20°C |
| Solubility | Hexane |
| Category | Research Tools; Enzyme Activators and Inhibitors; |
| Applications | Glycogen Synthase Kinase-3ß is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. TDZD-8 is a thiadiazolidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK-3ß ( IC50 =2nM). Binds to the active site of GSK-3ß. Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50 >100nM). |
| References | Martinez, A., et al.: J. Med. Chem., 45, 1292 (2002) |