Aprepitant
| Catalogue number: | A729800 |
| Chemical name: | Aprepitant |
| Synonyms: | 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; Emend; L 754030; MK 0869; MK 869; ONO 7436; |
| Impurity: | |
| CAS Number: | 170729-80-3 |
| Possible CAS #: | NA |
| Molecular form.: | C₂₃H₂₁F₇N₄O₃ |
| Appearance: | White to Pale Beige Solid |
| Melting Point: | 242-250°C |
| Mol. Weight: | 534.43 |
| Storage: | -20°C Freezer |
| Solubility: | DMSO (Slightly), Methanol (Slightly) |
| Stability: | No Data Available |
| Category: | Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, |
| Boiling Point: | No Data Available |
| Applications: | Aprepitant is a neurokinin-1 antagonist and an antiemetic agent (1). It is used to prevent chemotherapy-induced nausea and vomiting (CINV) in colorectal cancer patients (2) Aprepitant has also been shown to induce apoptotic cell death and G1 arrest through Akt/p53 axis in pre-B acute lymphoblastic leukemia cells (3). |
| Dangerous Goods Info: | NA |
| References: |
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| Peer Review Product Citations: | |
| MSDS: | A729800.pdf |
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