Catalogue number: A637475
Chemical name: Andrographolide
Synonyms: (3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone; [1R-[1α[E(S*)],4aβ,5α,6α,8aα]]-3-[2-[Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone; 3α,14,15,18-Tetrahydroxy-5β,9βH,10α-labda-8(20),12-dien-16-oic Acid γ-Lactone; Andrographis; Andrographolid
CAS Number: 5508-58-7
Possible CAS #: NA
Molecular form.: C₂₀H₃₀O₅
Appearance: White Solid
Melting Point: 229-232°C
Mol. Weight: 350.45
Storage: Refrigerator
Solubility: Acetic Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: Andrographolide is a labdane diterpenoid (2). Andrographolide is the main bioactive component isolated from the medicinal plant Andrographis paniculata (2). Andrographolide showed significant antihepatotoxic action in P. berghei K173-induced hepatic damage in M. natalensis(1). Andrographolide inhibits tumor necrosis factor-α (TNF-α)-induced intercellular adhesion mol.-1 (ICAM-1) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells (HUVEC), which are associated with inflammatory diseases (2). These findings suggest that Andrographolide may have potential as a cardiovascular-protective agent.
Dangerous Goods Info: NA

Peer Review Product Citations:
MSDS: A637475.pdf
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