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Pack Size Quantity Price (USD) Sub Total
500µg
$ 50.00 0.0
1mg
$ 55.00 0.0
2mg
$ 65.00 0.0
5mg
$ 85.00 0.0
10mg
$ 140.00 0.0
25mg
$ 360.00 0.0
Exact Weight Packaging
$ 75.00 / Vial 0.0
Total $ 0.0
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Product Description

Catalogue Number: A621350
Chemical Name: 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
Synonyms: N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediamine; QNZ;
CAS Number: 545380-34-5
Molecular Formula: C₂₂H₂₀N₄O
Appearance: Off-White to Dark Yellow Solid
Melting Point: >170°C (dec.)
Molecular Weight: 356.42
Storage: Refrigerator, Under Inert Atmosphere
Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
Category: Amines, Aromatics, Heterocycles, Inhibitors
Applications: QNZ is a novel inhibitor of NFkB which displays potent inhibitory effects on both NFKB transcriptional activation (IC50=11nM) and TNF-α production (IC50=7nM). It dose-dependently inhibited carragenin-induced edema formation in the rat paw model (1mg/Kg). A useful tool to explore the role of NFkB in cellular signaling pathways.
References
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