(1S,4R)-4-Amino-2-cyclopentene-1-methanol

Catalogue number: A603935
Chemical name: (1S,4R)-4-Amino-2-cyclopentene-1-methanol
Synonyms: (1S-cis)-4-Amino-2-cyclopentene-1-methanol;
Impurity:
CAS Number: 136522-35-5
Possible CAS #: NA
Molecular form.: C₆H₁₁NO
Appearance: No data available
Melting Point: No data available
Mol. Weight: 113.16
Storage: No Data Available
Solubility: No data available
Stability: No Data Available
Category: Chiral Reagents, Intermediates, Nucleotides, Bases & Related Reagents
Boiling Point: No Data Available
Applications: (1S,4R)-4-Amino-2-cyclopentene-1-methanol is a reagent for preparing cyclic ADP-carbocyclic-ribose analogs via Yoshikawa’s phosphorylation and cyclocondensation (1). (1S,4R)-4-Amino-2-cyclopentene-1-methanol is also an intermediate for the synthesis of Abacavir (A105000). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (2). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (3). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Dangerous Goods Info: NA
References:


Peer Review Product Citations:
MSDS: A603935.pdf
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