(1R,3S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopentanemethanol

Catalogue number: A603795
Chemical name: (1R,3S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopentanemethanol
Synonyms: Abacavir Impurity E; Abacavir Impurities; Abacavir EP Impurity E
Impurity: Abacavir EP Impurity E
CAS Number: 208762-35-0
Possible CAS #: NA
Molecular form.: C₁₄H₂₀N₆O
Appearance: Off-White Solid
Melting Point: 77-81ºC
Mol. Weight: 288.35
Storage: -20°C Freezer
Solubility: Methanol (Slightly), Water (Slightly)
Stability: No Data Available
Category: Impurities, Inhibitors, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: (1R,3S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopentanemethanol (Abacavir EP Impurity E) is an impurity of Abacavir (A104990). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Dangerous Goods Info: NA
References:

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  Pack size Price(USD)
5mg $175.00
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  Pack size Price(USD)
50mg $1400.00
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Exact Weight Packaging ($75(USD) / Vial)
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Inventory Status:   In Stock



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