(1S,4R)-cis-4-Amino-2-cyclopentene-1-methanol D-Tartrate

Catalogue number: A603640
Chemical name: (1S,4R)-cis-4-Amino-2-cyclopentene-1-methanol D-Tartrate
Synonyms: (1S-cis)-4-Amino-2-cyclopentene-1-methanol D-Tartrate; (1S,4R)-cis-4-Amino-2-cyclopentene-1-methanol (2S,3S)-2,3-Dihydroxybutanedioate; Abacavir - In House Impurity; Abacavir Impurities
Impurity: Abacavir - In House Impurity
CAS Number: 229177-52-0
Possible CAS #: NA
Molecular form.: C₁₀H₁₇NO₇
Appearance: White Solid
Melting Point: 125 -127°C
Mol. Weight: 263.24
Storage: Refrigerator
Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
Stability: No Data Available
Category: Chiral Reagents, Intermediates, Nucleotides, Bases & Related Reagents,
Boiling Point: No Data Available
Applications: (1S,4R)-cis-4-Amino-2-cyclopentene-1-methanol D-Tartrate (Abacavir - In House Impurity) is an intermediate of Abacavir (A104990). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:
MSDS: A603640.pdf

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