(1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride
| Catalogue Number: | A603506 |
| Chemical Name: | (1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride |
| Synonyms: | (1S-cis)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Monohydrochloride; Abacavir USP Related Compound C USP; Abacavir Related Compound C; Abacavir Impurities; Abacavir Intermediates; Abacavir USP RC C |
| Impurity: | Abacavir USP Related Compound C |
| CAS Number: | 172015-79-1 |
| Alternate CAS #: | Free Base: 136522-33-3 |
| Molecular Formula: | C₁₁H₁₃Cl₂N₅O |
| Appearance: | Off-White to Beige to Brown Solid |
| Melting Point: | >154°C (dec.) |
| Molecular Weight: | 302.16 |
| Storage: | Refrigerator, Under Inert Atmosphere |
| Solubility: | DMSO (Slightly), Methanol (Slightly) |
| Category: | Intermediate, Pharmaceuticals, Intermediates & Fine Chemicals, Nucleotides, Bases & Related Reagents |
| Applications: | (1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride (Abacavir Related Compound C) is an intermediate of Abacavir (A104990). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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All Products are stable to be shipped at room temperature, unless otherwise specified. |
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| MSDS: | A603506.pdf |
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