(1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride

Catalogue number: A603506
Chemical name: (1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride
Synonyms: (1S-cis)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Monohydrochloride; Abacavir USP Related Compound C USP; Abacavir Related Compound C; Abacavir Impurities; Abacavir Intermediates
Impurity: Abacavir Related Compound C
CAS Number: 172015-79-1
Possible CAS #: NA
Molecular form.: C₁₁H₁₃Cl₂N₅O
Appearance: Off-White to Tan Solid
Melting Point: 187-189°C
Mol. Weight: 302.16
Storage: Refrigerator, Under Inert Atmosphere
Solubility: DMSO (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Intermediate, Pharmaceuticals, Intermediates & Fine Chemicals, Nucleotides, Bases & Related Reagents
Boiling Point: No Data Available
Applications: (1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride (Abacavir Related Compound C) is an intermediate of Abacavir (A104990). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:
MSDS: A603506.pdf

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