A603506 Chemical Structure

All Products are stable to be shipped at room temperature, unless otherwise specified.
Pack SizeQuantityPrice (USD)Sub Total
100mg
$ 65.000.0
250mg
$ 95.000.0
1g
$ 140.000.0
5g
$ 645.000.0
10g
$ 970.000.0
25g
$ 1760.000.0
Exact Weight Packaging
$ 95.000.0
Total$ 0.0
  • Request another packsize ? Click here.
  • Inventory Status : In Stock
  • Ships On :
A603506

Bulk Order Request for A603506

#Pack SizeUnitQuantity
1.
2.
3.
4.
5.

Product Description

Catalogue NumberA603506
Chemical Name(1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride
Synonyms(1S-cis)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Monohydrochloride; Abacavir USP Related Compound C USP; Abacavir Related Compound C; Abacavir Impurities; Abacavir Intermediates; Abacavir USP RC C
ImpurityAbacavir USP Related Compound C
CAS Number172015-79-1
Alternate CAS #Free Base: 136522-33-3
Molecular FormulaC₁₁H₁₃Cl₂N₅O
AppearanceOff-White to Beige to Brown Solid
Melting Point>154°C (dec.)
Molecular Weight302.16
Storage4°C, Inert atmosphere
SolubilityDMSO (Slightly), Methanol (Slightly)
Category Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications(1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride (Abacavir Related Compound C) is an intermediate of Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References