| Catalogue number: |
A603506 |
| Chemical name: |
(1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride |
| Synonyms: |
(1S-cis)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Monohydrochloride; Abacavir USP Related Compound C USP; Abacavir Related Compound C; Abacavir Impurities; Abacavir Intermediates |
| Impurity: |
Abacavir Related Compound C |
| CAS Number: |
172015-79-1 |
| Possible CAS #: |
NA |
| Molecular form.: |
C₁₁H₁₃Cl₂N₅O |
| Appearance: |
Off-White to Tan Solid |
| Melting Point: |
187-189°C |
| Mol. Weight: |
302.16 |
| Storage: |
Refrigerator, Under Inert Atmosphere |
| Solubility: |
DMSO (Slightly), Methanol (Slightly) |
| Stability: |
No Data Available |
| Category: |
Intermediate, Pharmaceuticals, Intermediates & Fine Chemicals, Nucleotides, Bases & Related Reagents |
| Boiling Point: |
No Data Available |
| Applications: |
(1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride (Abacavir Related Compound C) is an intermediate of Abacavir (A104990). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
| Dangerous Goods Info: |
NA |
| References: |
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| Peer Review Product Citations: |
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| MSDS: |
A603506.pdf
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