A192000 Chemical Structure

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Product Description

Catalogue NumberA192000
Chemical Name(-)-Actinonin
Synonyms(2R)-N4-Hydroxy-N1-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-butanediamide; Actinonine; 3-[[1-[[2-(Hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamoyl]octanohydroxamic Acid; Actinonin; CONA 57; Ro 06-1467;
CAS Number13434-13-4
Molecular FormulaC₁₉H₃₅N₃O₅
AppearanceWhite to Light Beige Solid
Melting Point137-139°C
Molecular Weight385.5
Storage-20°C Freezer
SolubilityDMSO (Slightly), Methanol (Slightly)
Category Standards; Chiral Molecules; Enzyme Activators and Inhibitors; Others; Pharmaceutical/API Drug Impurities/Metabolites; Antibotics;
Applications(-)-Actinonin is a bioactive peptide and antibiotic that is a potent inhibitor of aminopeptidase M and leucine aminopeptidase. Actinonin has observed to be an inhibitor of peptide deformylase, meprin A, and thermolysin. Actinonin also inhibits tumor cell invasion and matrix degradation along with displayed antitumor activity in vitro and in vivo as well as acting as an apoptotic inducer.
ReferencesUmezawa, H., et al.: J. Antibiot., 38, 1629 (1985), Escobar-Alvarez, S., et al.: J. Mol. Biol., 387, 1211 (2009), Berg, A., et al.: Biochem., 48, 1584 (2009), Kuehlmann, U., et al.: Life Sci., 84, 1 (2009),