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| Pack Size | Quantity | Price (USD) | Sub Total |
|---|---|---|---|
| 1mg | $ 135.00 | 0.0 | |
| 5mg | $ 540.00 | 0.0 | |
| 10mg | $ 1040.00 | 0.0 | |
| Exact Weight Packaging | $ 145.00 | 0.0 | |
| Total | $ 0.0 | ||
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A115610
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Product Description
| Catalogue Number | A115610 |
| Chemical Name | Acalabrutinib Acetaldehyde |
| Synonyms | (S)-4-(8-Amino-3-(1-(3-oxobutanoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide |
| Alternate CAS # | 1420477-60-6 |
| Molecular Formula | C₂₆H₂₅N₇O₃ |
| Molecular Weight | 483.52 |
| Category | Standards; Pharmaceutical/API Drug Impurities/Metabolites; |
| Applications | Acalabrutinib Acetaldehyde is an impurity of Acalabrutinib (A115605). Acalabrutinib, is an experimental anti-cancer drug and a selective Bruton's tyrosine kinase (BTK) inhibitor. This kinase transmits signals from B-cell Receptor (BCR), and thus any genetic BTK mutation causes B-Cell immunodeficiency. Therefore, BTK inhibitors targeting B-cell signaling has shown great promise for the treatment of chronic lymphocytic leukemia (CLL). |
| References | Byrd; et al. (2015). "Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia."; "AstraZeneca to buy Acerta for blood cancer drug". www.rsc.org. Chemistry World - Royal Society of Chemistry. Retrieved 24 December 2015. |