A115605 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
2.5mg
$ 50.000.0
5mg
$ 90.000.0
10mg
$ 130.000.0
25mg
$ 240.000.0
100mg
$ 625.000.0
250mg
$ 870.000.0
Exact Weight Packaging
$ 145.000.0
Total$ 0.0
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A115605

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Product Description

Catalogue NumberA115605
Chemical NameAcalabrutinib
Synonyms4-[8-amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide; ACP 196
CAS Number1420477-60-6
Molecular FormulaC₂₆H₂₃N₇O₂
AppearanceLight Yellow to Yellow Solid
Melting Point>133°C (dec.)
Molecular Weight465.51
Storage4°C
SolubilityDMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
Category Standards; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsAcalabrutinib, is an experimental anti-cancer drug and a selective Bruton's tyrosine kinase (BTK) inhibitor. This kinase transmits signals from B-cell Receptor (BCR), and thus any genetic BTK mutation causes B-Cell immunodeficiency. Therefore, BTK inhibitors targeting B-cell signaling has shown great promise for the treatment of chronic lymphocytic leukemia (CLL).
References'Byrd; et al. (2015). ''Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia.''; ''AstraZeneca to buy Acerta for blood cancer drug''. www.rsc.org. Chemistry World - Royal Society of Chemistry. Retrieved 24 December 2015.'