A115154 Chemical Structure

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1mg
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5mg
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10mg
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A115154

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Product Description

Catalogue NumberA115154
Chemical NameAbemaciclib-D5
SynonymsN-[5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinamine-d4; LY 2835219-d4; N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine-d4
CAS Number1809251-51-1
Molecular FormulaC₂₇H₂₇D₅F₂N₈
Molecular Weight511.64
Category Building Blocks; Isotopic Labeled Analogues;
ApplicationsIsotope labelled Abemaciclib is a potent and selective inhibitor of cyclin-dependent kinases, CDK4 and CDK6, as a method to inhibit the proliferation of cancer cells.
ReferencesO'Leary, Ben., et al.: Nat Rev Clin Oncol.,  13, 417 (2016); Van Arsdale., et al.: Clin. Cancer Res., 21, 2905 (2015);