A112580 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
5mg
$ 55.000.0
10mg
$ 65.000.0
25mg
$ 95.000.0
50mg
$ 155.000.0
100mg
$ 215.000.0
250mg
$ 340.000.0
Exact Weight Packaging
$ 145.000.0
Total$ 0.0
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  • Inventory Status : Pending QC
  • Ships On : 2/23/2023
A112580

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Product Description

Catalogue NumberA112580
Chemical NameABT 888
Synonyms2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide; A 861695;
CAS Number912444-00-9
Molecular FormulaC₁₃H₁₆N₄O
AppearanceOff-White to Dark Yellow Solid
Melting Point>173°C (dec.)
Molecular Weight244.29
Storage4°C
SolubilityMethanol (Slightly, Heated), THF (Slightly, Heated)
Category Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo. Potent PARP inhibitor.
ReferencesVirag, L., et al.: Pharmacol. Rev., 54, 375