A112552 Chemical Structure

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A112552

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Product Description

Catalogue NumberA112552
Chemical NameABT 737-d8
Synonyms4-[4-[(4’-Chloro[1,1’-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide-d8;
CAS Number1217686-68-4
Molecular FormulaC₄₂H₃₇D₈ClN₆O₅S₂
AppearanceYellow Solid
Melting Point148-150˚C
Molecular Weight821.48
Storage-20°C
SolubilityDMSO
Category Standards; Chiral Molecules; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsA selective inhibitor of BCL-2, in small cell lung cancer. ABT-737 induced dramatic regressions in tumors derived from some SCLC cell lines.
ReferencesIkegaki, N., et al.: Cancer Res., 54, 6 (1994), Kaiser, U., et al.: Lung Cancer, 15, 31 (1996), Rudin, C., et al.: J. Clin. Oncol., 22, 1110 ( 2004), Konopleva, M., et al.: Cancer Cell, 10, 375 (2006), Trudel, S., et al.: Clin. Cancer Res., 13, 621 (2007),