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Pack Size | Quantity | Price (USD) | Sub Total |
---|---|---|---|
1mg | $ 190.00 | 0.0 | |
10mg | $ 1487.00 | 0.0 | |
Exact Weight Packaging | $ 145.00 | 0.0 | |
Total | $ 0.0 |
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A112552
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Product Description
Catalogue Number | A112552 |
Chemical Name | ABT 737-d8 |
Synonyms | 4-[4-[(4’-Chloro[1,1’-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide-d8; |
CAS Number | 1217686-68-4 |
Molecular Formula | C₄₂H₃₇D₈ClN₆O₅S₂ |
Appearance | Yellow Solid |
Melting Point | 148-150˚C |
Molecular Weight | 821.48 |
Storage | -20°C |
Solubility | DMSO |
Category | Standards; Chiral Molecules; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
Applications | A selective inhibitor of BCL-2, in small cell lung cancer. ABT-737 induced dramatic regressions in tumors derived from some SCLC cell lines. |
References | Ikegaki, N., et al.: Cancer Res., 54, 6 (1994), Kaiser, U., et al.: Lung Cancer, 15, 31 (1996), Rudin, C., et al.: J. Clin. Oncol., 22, 1110 ( 2004), Konopleva, M., et al.: Cancer Cell, 10, 375 (2006), Trudel, S., et al.: Clin. Cancer Res., 13, 621 (2007), |