A112432 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
1mg
$ 196.000.0
5mg
$ 896.000.0
10mg
$ 1642.000.0
25mg
$ 3559.000.0
Exact Weight Packaging
$ 145.000.0
Total$ 0.0
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A112432

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Product Description

Catalogue NumberA112432
Chemical NameABT-199-D10
SynonymsVenetoclax-d10
Molecular FormulaC₄₅H₄₀D₁₀ClN₇O₇S
Molecular Weight878.5
Category Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsABT-199-D10 is a deuterized form of ABT 199 (A112430), which is a potent and selective BCL-2 inhibitor that achieves potent antitumor activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.
ReferencesDavids, M. & Letai, A.: Cancer Cell, 23, 139 (2013); Souers, A.,et al.: Nat. Med., 19, 202 (2013); Vaillant, F., et al.: Cancer Cell, 24, 120 (2013); Vogler, M., et al.: Brit. J. Haematol., 163, 139 (2013);