A112425 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
10mg
$ 85.000.0
50mg
$ 140.000.0
100mg
$ 195.000.0
500mg
$ 565.000.0
Exact Weight Packaging
$ 145.000.0
Total$ 0.0
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A112425

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Product Description

Catalogue NumberA112425
Chemical NameABT 199 (>99%)(Venetoclax)
Synonyms4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
CAS Number1257044-40-8
Molecular FormulaC₄₅H₅₀ClN₇O₇S
AppearancePale Yellow to Light Yellow Solid
Melting Point>150°C (dec.)
Molecular Weight868.44
Storage-20°C
SolubilityDMSO (Slightly)
Category Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsABT 199 (>99%) is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.
ReferencesDavids, M. & Letai, A.: Cancer Cell, 23, 139 (2013); Souers, A.,et al.: Nat. Med., 19, 202 (2013); Vaillant, F., et al.: Cancer Cell, 24, 120 (2013); Vogler, M., et al.: Brit. J. Haematol., 163, 139 (2013);