A108485 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
5mg
$ 60.000.0
10mg
$ 95.000.0
mg25
$ 210.000.0
50mg
$ 390.000.0
100mg
$ 760.000.0
250mg
$ 1655.000.0
Exact Weight Packaging
$ 95.000.0
Total$ 0.0
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A108485

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Product Description

Catalogue NumberA108485
Chemical NameAbiraterone 3-((1-Chloroethyl)sulfinyl)benzene
Synonyms(8R,9S,10R,13S,14S)-3-(1-Chloro-1-(phenylsulfinyl)ethyl)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,6,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol;
Molecular FormulaC32H38ClNO2S
AppearanceBeige Solid
Molecular Weight536.17
SolubilityDichloromethane, Ethyl Acetate, Methanol
Category Standards; Chiral Molecules; Steroids; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsAbiraterone 3-((1-Chloroethyl)sulfinyl)benzene is an intermediate in synthesizing 3-Deoxy-3-acetylabiraterone-3-ene (D232060), which is an impurity of Abiraterone (A108490), a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.
ReferencesDenis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389 (2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005);