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|Pack Size||Quantity||Price (USD)||Sub Total|
|Exact Weight Packaging||$ 145.00||0.0|
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|Chemical Name||Abacavir Triphosphate TEA Salt|
|Synonyms||P-[[(2S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopenten-1-yl]methyl]ester Triphosphate TEA Salt|
|Alternate CAS #||Free acid: 137820-58-7|
|Molecular Formula||C₁₄H₂₁N₆O₁₀P₃ • xC ₆H₁₅N|
|Appearance||Off-White to Pale Beige Solid|
|Melting Point||>104C (dec.)|
|Molecular Weight||526.27 + (101.19)x|
|Solubility||Methanol (Slightly), Water (Slightly)|
|Category||Research Tools; Molecular Biology; Enzyme Activators and Inhibitors;|
|Applications||Abacavir Triphosphate TEA Salt, is a metabolite of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.|