A105045 Chemical Structure

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Product Description

Catalogue NumberA105045
Chemical NameAbacavir Triphosphate TEA Salt
SynonymsP-[[(2S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopenten-1-yl]methyl]ester Triphosphate TEA Salt
Alternate CAS #Free acid: 137820-58-7
Molecular FormulaC₁₄H₂₁N₆O₁₀P₃ • xC ₆H₁₅N
AppearanceOff-White to Pale Beige Solid
Melting Point>104C (dec.)
Molecular Weight526.27 + (101.19)x
Storage-20°C, Hygroscopic
SolubilityMethanol (Slightly), Water (Slightly)
Category Research Tools; Molecular Biology; Enzyme Activators and Inhibitors;
ApplicationsAbacavir Triphosphate TEA Salt, is a metabolite of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.