Abacavir Triphosphate Trisodium Salt DISCONTINUED. Please see A105045.

Catalogue number: A105040
Chemical name: Abacavir Triphosphate Trisodium Salt DISCONTINUED. Please see A105045.
Synonyms: P-[[(2S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopenten-1-yl]methyl]ester Triphosphate Trisodium Salt
Impurity:
CAS Number: NA
Possible CAS #: NA
Molecular form.: C₁₄H₁₈N₆Na₃O₁₀P₃
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 592.22
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Metabolites & Impurities, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals, Phosphorylating and Phosphitylating Agents
Boiling Point: No Data Available
Applications: Abacavir Triphosphate Trisodium Salt is a metabolite of Abacavir. Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Dangerous Goods Info: NA
References:

Peer Review Product Citations:
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