All Products are stable to be shipped at room temperature, unless otherwise specified.
|Pack Size||Quantity||Price (USD)||Sub Total|
|Exact Weight Packaging||$ 95.00||0.0|
Product successfully added to cart.
- Request another packsize ? Click here.
- Inventory Status : Currently Back Ordered - Please Request Lead Time
- Ships On :
Bulk Order Request for A105035
|Chemical Name||Abacavir 5’-4-Chloro-6-methylpyrimidine-2,5-diamine|
|Synonyms||N6-Cyclopropyl-9-((1R,4S)-4-(((2,5-diamino-6-chloropyrimidin-4-yl)oxy)methyl)cyclopent-2-en-1-yl)-9H-purine-2,6-diamine; Abacavir USP Related Compound D; Abacavir EP Impurity B; ; Abacavir Impurities;Abacavir EP Impurity B / USP - D|
|Impurity||Abacavir EP Impurity B|
|Category||Standards; Pharmaceutical/API Drug Impurities/Metabolites;|
|Applications||Abacavir 5’-4-Chloro-6-methylpyrimidine-2,5-diamine (Abacavir EP Impurity B) is a degradation product of Abacavir Sulfate (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.|