Abacavir 5’-4-Chloro-6-methylpyrimidine-2,5-diamine

Catalogue number: A105035
Chemical name: Abacavir 5’-4-Chloro-6-methylpyrimidine-2,5-diamine
Synonyms: N6-Cyclopropyl-9-((1R,4S)-4-(((2,5-diamino-6-chloropyrimidin-4-yl)oxy)methyl)cyclopent-2-en-1-yl)-9H-purine-2,6-diamine; Abacavir Related Compound D
CAS Number: 1443421-69-9
Possible CAS #: NA
Molecular form.: C₁₈H₂₁ClN₁₀O
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 428.88
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Metabolites & Impurities, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: Abacavir 5’-4-Chloro-6-methylpyrimidine-2,5-diamine is a degradation product of Abacavir Sulfate (A105000). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Dangerous Goods Info: NA
References: PMID: 22267465
PMID: 18479171
Peer Review Product Citations:

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