A105035 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
2.5mg
$ 135.000.0
25mg
$ 1085.000.0
Exact Weight Packaging
$ 95.000.0
Total$ 0.0
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A105035

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Product Description

Catalogue NumberA105035
Chemical NameAbacavir 5’-4-Chloro-6-methylpyrimidine-2,5-diamine
SynonymsN6-Cyclopropyl-9-((1R,4S)-4-(((2,5-diamino-6-chloropyrimidin-4-yl)oxy)methyl)cyclopent-2-en-1-yl)-9H-purine-2,6-diamine; Abacavir USP Related Compound D; Abacavir EP Impurity B; ; Abacavir Impurities;Abacavir EP Impurity B / USP - D
ImpurityAbacavir EP Impurity B
CAS Number1443421-69-9
Molecular FormulaC18H21ClN10O
Molecular Weight428.88
Category Standards; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsAbacavir 5’-4-Chloro-6-methylpyrimidine-2,5-diamine (Abacavir EP Impurity B) is a degradation product of Abacavir Sulfate (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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