A105030 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
1mg
$ 165.000.0
10mg
$ 1295.000.0
Exact Weight Packaging
$ 145.000.0
Total$ 0.0
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A105030

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Product Description

Catalogue NumberA105030
Chemical NameAbacavir 5’-(2,3,4-Tri-O-isobytyryl)-β-D-glucuronic Acid Methyl Ester
Molecular FormulaC33H46N6O10
AppearanceOff-White Solid
Molecular Weight686.75
SolubilityChloroform, Dichloromethane, DMSO, Methanol
Category Standards; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsAbacavir 5’-(2,3,4-Tri-O-isobytyryl)-β-D-glucuronic Acid Methyl Ester is an intermediate used in the synthesis of various Abacavir metabolites. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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