Abacavir 5’-(2,3,4-Tri-O-isobytyryl)-β-D-glucuronic Acid Methyl Ester

Catalogue number: A105030
Chemical name: Abacavir 5’-(2,3,4-Tri-O-isobytyryl)-β-D-glucuronic Acid Methyl Ester
Synonyms:
Impurity:
CAS Number: NA
Possible CAS #: NA
Molecular form.: C₃₃H₄₆N₆O₁₀
Appearance: Off-White Solid
Melting Point: No Data Available
Mol. Weight: 686.75
Storage: No Data Available
Solubility: Chloroform, Dichloromethane, DMSO, Methanol
Stability: No Data Available
Category: Amines, Aromatics, Glucuronides, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: Abacavir 5’-(2,3,4-Tri-O-isobytyryl)-β-D-glucuronic Acid Methyl Ester is an intermediate used in the synthesis of various Abacavir metabolites. Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Dangerous Goods Info: NA
References:

Peer Review Product Citations:
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Order Product

  Pack size Price(USD)
1mg $140.00
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  Pack size Price(USD)
10mg $1120.00
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Exact Weight Packaging ($75(USD) / Vial)
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Inventory Status:   Pending QC



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