A105025 Chemical Structure

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5mg
$ 165.000.0
50mg
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A105025

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Product Description

Catalogue NumberA105025
Chemical Namerac-Abacavir Sulfate
SynonymsAbacavir Sulfate Racemic; (4-[2-Amino-6-(cyclopropylamino)-9H-purin-9yl]-2-cyclopentene-1-methanol Sulfate (2:1);
Alternate CAS #Racemic Mixture: 136470-79-6/188062-50-2
Molecular FormulaC28H38N12O6S
Molecular Weight670.47
Category Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; Anti-virals/Anti-retrovirals;
Applicationsrac-Abacavir Sulfate is a racemic mixture of ent-Abacavir (A105015) and Abacavir Sulfate (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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