Abacavir 5’-Phosphate
| Catalogue number: | A105020 |
| Chemical name: | Abacavir 5’-Phosphate |
| Synonyms: | (1S,4R)- 4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Dihydrogen Phosphate (Ester); (1S-cis)-Abacavir Monophosphate; Abacavir - In House Impurity; Abacavir Impurities; Abacavir Metabolites |
| Impurity: | Abacavir - In House Impurity |
| CAS Number: | 136470-77-4 |
| Alternate CAS #: | NA |
| Molecular form.: | C₁₄H₁₉N₆O₄P |
| Appearance: | White Solid |
| Melting Point: | 189-194°C (dec.) |
| Mol. Weight: | 366.31 |
| Storage: | -20˚C Freezer |
| Solubility: | Methanol, Water |
| Stability: | No Data Available |
| Category: | Metabolites & Impurities, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals, Phosphorylating and Phosphitylating Agents, |
| Boiling Point: | No Data Available |
| Applications: | Abacavir 5’-Phosphate (Abacavir - In House Impurity) is a metabolite of Abacavir (A105000). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
| Dangerous Goods Info: | NA |
| References: |
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All Products are stable to be shipped at room temperature, unless otherwise specified. |
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| MSDS: | A105020.pdf |
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