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Pack Size Quantity Price (USD) Sub Total
1mg
$ 80.00 0.0
2mg
$ 150.00 0.0
2.5mg
$ 175.00 0.0
5mg
$ 315.00 0.0
10mg
$ 567.00 0.0
25mg
$ 1275.00 0.0
Exact Weight Packaging
$ 75.00 / Vial 0.0
Total $ 0.0
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Product Description

Catalogue Number: A105020
Chemical Name: Abacavir 5’-Phosphate
Synonyms: (1S,4R)- 4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Dihydrogen Phosphate (Ester); (1S-cis)-Abacavir Monophosphate; Abacavir - In House Impurity; Abacavir Impurities; Abacavir Metabolites
Impurity: Abacavir - In House Impurity
CAS Number: 136470-77-4
Molecular Formula: C₁₄H₁₉N₆O₄P
Appearance: White Solid
Melting Point: 189-194°C (dec.)
Molecular Weight: 366.31
Storage: -20˚C Freezer
Solubility: Methanol, Water
Category: Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications: Abacavir 5’-Phosphate (Abacavir - In House Impurity) is a metabolite of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References
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