Abacavir 5’-Phosphate

Catalogue number: A105020
Chemical name: Abacavir 5’-Phosphate
Synonyms: (1S,4R)- 4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Dihydrogen Phosphate (Ester); (1S-cis)-Abacavir Monophosphate; Abacavir - In House Impurity; Abacavir Impurities; Abacavir Metabolites
Impurity: Abacavir - In House Impurity
CAS Number: 136470-77-4
Possible CAS #: NA
Molecular form.: C₁₄H₁₉N₆O₄P
Appearance: White Solid
Melting Point: 189-194°C (dec.)
Mol. Weight: 366.31
Storage: -20˚C Freezer
Solubility: Methanol, Water
Stability: No Data Available
Category: Metabolites & Impurities, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals, Phosphorylating and Phosphitylating Agents,
Boiling Point: No Data Available
Applications: Abacavir 5’-Phosphate (Abacavir - In House Impurity) is a metabolite of Abacavir (A105000). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:
MSDS: A105020.pdf

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