A105020 Chemical Structure

All Products are stable to be shipped at room temperature, unless otherwise specified.
Pack SizeQuantityPrice (USD)Sub Total
1mg
$ 100.000.0
2mg
$ 175.000.0
2.5mg
$ 210.000.0
5mg
$ 370.000.0
10mg
$ 665.000.0
25mg
$ 1490.000.0
Exact Weight Packaging
$ 145.000.0
Total$ 0.0
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A105020

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Product Description

Catalogue NumberA105020
Chemical NameAbacavir 5’-Phosphate
Synonyms(1S,4R)- 4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol
ImpurityAbacavir - In House Impurity
CAS Number136470-77-4
Molecular FormulaC₁₄H₁₉N₆O₄P
AppearanceWhite Solid
Melting Point189-194°C (dec.)
Molecular Weight366.31
Storage-20°C
SolubilityMethanol, Water
Category Standards; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsAbacavir 5’-Phosphate (Abacavir - In House Impurity) is a metabolite of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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