A105015 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
1mg
$ 110.000.0
2.5mg
$ 205.000.0
25mg
$ 1620.000.0
Exact Weight Packaging
$ 145.000.0
Total$ 0.0
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A105015

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Product Description

Catalogue NumberA105015
Chemical Nameent-Abacavir
Synonyms(1R,4S)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol;
ImpurityAbacavir EP Impurity A
CAS Number136470-79-6
Molecular FormulaC₁₄H₁₈N₆O
AppearanceOff-White to Pale Yellow Solid
Melting Point>77°C (dec.)
Molecular Weight286.33
Storage4°C
SolubilityDMSO (Slightly), Methanol (Slightly)
Category Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applicationsent-Abacavir (Abacavir EP Impurity A) is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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