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$ 1400.00 0.0
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Product Description

Catalogue Number: A105002
Chemical Name: Abacavir-d4
Synonyms: (1S,4R)-4-[2-Amino-6-(cyclopropylamino-d4)-9H-purin-9-yl]-2-cyclopentene-1-methanol;(1S-cis)-4-[2-Amino-6-(cyclopropylamino-d4)-9H-purin-9-yl]-2-cyclopentene- 1-methanol; 1592U89-d4; ABC-d4; Abacavir Stable Isotope
CAS Number: 1217731-56-0
Alternate CAS #: 136470-78-5-unlabelled
Molecular Formula: C₁₄H₁₄D₄N₆O
Appearance: Off-White to Light Beige Solid
Melting Point: >70°C (dec.)
Molecular Weight: 290.36
Storage: Hygroscopic, -20˚C Freezer, Under Inert Atmosphere
Solubility: DMSO (Slightly), Methanol (Slightly)
Stability: Very Hygroscopic
Category: Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
Applications: Abacavir-d4 is deuterium labeled Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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