A105002 Chemical Structure

All Products are stable to be shipped at room temperature, unless otherwise specified.
Pack SizeQuantityPrice (USD)Sub Total
1mg
$ 220.000.0
10mg
$ 1720.000.0
Exact Weight Packaging
$ 145.000.0
Total$ 0.0
  • Request another packsize ? Click here.
  • Inventory Status : In Stock
  • Ships On :
A105002

Bulk Order Request for A105002

#Pack SizeUnitQuantity
1.
2.
3.
4.
5.

Product Description

Catalogue NumberA105002
Chemical NameAbacavir-d4
Synonyms(1S,4R)-4-[2-Amino-6-(cyclopropylamino-d4)-9H-purin-9-yl]-2-cyclopentene-1-methanol;(1S-cis)-4-[2-Amino-6-(cyclopropylamino-d4)-9H-purin-9-yl]-2-cyclopentene-
CAS Number1217731-56-0
Alternate CAS #136470-78-5-unlabelled
Molecular FormulaC₁₄H₁₄D₄N₆O
AppearanceOff-White to Light Beige Solid
Melting Point>70°C (dec.)
Molecular Weight290.36
Storage-20°C, Hygroscopic
SolubilityDMSO (Slightly), Methanol (Slightly)
StabilityVery Hygroscopic
Category Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsAbacavir-d4 is deuterium labeled Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References