Abacavir-d4

Catalogue number: A105002
Chemical name: Abacavir-d4
Synonyms: (1S,4R)-4-[2-Amino-6-(cyclopropylamino-d4)-9H-purin-9-yl]-2-cyclopentene-1-methanol;(1S-cis)-4-[2-Amino-6-(cyclopropylamino-d4)-9H-purin-9-yl]-2-cyclopentene- 1-methanol; 1592U89-d4; ABC-d4; Abacavir Stable Isotope
Impurity:
CAS Number: 1217731-56-0
Possible CAS #: NA
Molecular form.: C₁₄H₁₄D₄N₆O
Appearance: Off-White to Light Beige Solid
Melting Point: 84-98°C
Mol. Weight: 290.36
Storage: Hygroscopic, -20˚C Freezer, Under Inert Atmosphere
Solubility: DMSO, Methanol
Stability: No Data Available
Category: Isotope Labelled Compounds, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: Abacavir-d4 is deuterium labeled Abacavir (A104990). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Dangerous Goods Info: NA
References: PMID: 22267465
PMID: 18479171
Peer Review Product Citations:

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1mg $175.00
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10mg $1400.00
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Exact Weight Packaging ($75(USD) / Vial)
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Inventory Status:   In Stock



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