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| Pack Size | Quantity | Price (USD) | Sub Total |
|---|---|---|---|
| 1mg | $ 220.00 | 0.0 | |
| 10mg | $ 1720.00 | 0.0 | |
| Exact Weight Packaging | $ 145.00 | 0.0 | |
| Total | $ 0.0 | ||
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A105002
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Product Description
| Catalogue Number | A105002 |
| Chemical Name | Abacavir-d4 |
| Synonyms | (1S,4R)-4-[2-Amino-6-(cyclopropylamino-d4)-9H-purin-9-yl]-2-cyclopentene-1-methanol;(1S-cis)-4-[2-Amino-6-(cyclopropylamino-d4)-9H-purin-9-yl]-2-cyclopentene- |
| CAS Number | 1217731-56-0 |
| Alternate CAS # | 136470-78-5-unlabelled |
| Molecular Formula | C₁₄H₁₄D₄N₆O |
| Appearance | Off-White to Light Beige Solid |
| Melting Point | >70°C (dec.) |
| Molecular Weight | 290.36 |
| Storage | -20°C, Hygroscopic |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Stability | Very Hygroscopic |
| Category | Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites; |
| Applications | Abacavir-d4 is deuterium labeled Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
| References |