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|Pack Size||Quantity||Price (USD)||Sub Total|
|Exact Weight Packaging||$ 145.00||0.0|
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|Chemical Name||Abacavir Sulfate|
|Synonyms||(1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Sulfate; Ziagen; Abacavir - In House Impurity; Abacavir Impurities; Abacavir Intermediates|
|Impurity||Abacavir - In House Impurity|
|Alternate CAS #||free base: 136470-78-5|
|Appearance||White to Off-White Solid|
|Melting Point||>205°C (dec.)|
|Storage||-20°C, Inert atmosphere|
|Solubility||Methanol (Slightly), Water (Slightly)|
|Category||Standards; Pharmaceutical/API Drug Impurities/Metabolites;|
|Applications||Abacavir Sulfate (Abacavir - In House Impurity) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.|