Abacavir Sulfate

Catalogue number: A105000
Chemical name: Abacavir Sulfate
Synonyms: (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Sulfate; Ziagen; Abacavir - In House Impurity; Abacavir Impurities; Abacavir Intermediates
Impurity: Abacavir - In House Impurity
CAS Number: 188062-50-2
Possible CAS #: NA
Molecular form.: C₂₈H₃₈N₁₂O₆S
Appearance: White to Off-White Solid
Melting Point: 213 - 214°C (dec.)
Mol. Weight: 670.74
Storage: -20°C Freezer
Solubility: Water, Methanol (Sparingly)
Stability: No Data Available
Category: Inhibitors, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: Abacavir Sulfate (Abacavir - In House Impurity) is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Dangerous Goods Info: NA
References: PMID: 22267465
PMID: 18479171
Peer Review Product Citations:

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50mg $95.00
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5g $225.00
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