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Pack Size Quantity Price (USD) Sub Total
10mg
$ 65.00 0.0
50mg
$ 95.00 0.0
100mg
$ 125.00 0.0
5g
$ 225.00 0.0
Exact Weight Packaging
$ 75.00 / Vial 0.0
Total $ 0.0
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Inventory Status : In Stock

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Product Description

Catalogue Number: A105000
Chemical Name: Abacavir Sulfate
Synonyms: (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Sulfate; Ziagen; Abacavir - In House Impurity; Abacavir Impurities; Abacavir Intermediates
Impurity: Abacavir - In House Impurity
CAS Number: 188062-50-2
Alternate CAS #: free base: 136470-78-5
Molecular Formula: C₂₈H₃₈N₁₂O₆S
Appearance: White to Off-White Solid
Melting Point: >205°C (dec.)
Molecular Weight: 670.74
Storage: -20°C Freezer, Under inert atmosphere
Solubility: Methanol (Slightly), Water (Slightly)
Category: Inhibitors, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals,
Applications: Abacavir Sulfate (Abacavir - In House Impurity) is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References
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