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| Pack Size | Quantity | Price (USD) | Sub Total |
|---|---|---|---|
| 10mg | $ 80.00 | 0.0 | |
| 100mg | $ 161.00 | 0.0 | |
| 5g | $ 276.00 | 0.0 | |
| Exact Weight Packaging | $ 145.00 | 0.0 | |
| Total | $ 0.0 | ||
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A105000
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Product Description
| Catalogue Number | A105000 |
| Chemical Name | Abacavir Sulfate |
| Synonyms | (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Sulfate; Ziagen; Abacavir - In House Impurity; Abacavir Impurities; Abacavir Intermediates |
| Impurity | Abacavir - In House Impurity |
| CAS Number | 188062-50-2 |
| Alternate CAS # | free base: 136470-78-5 |
| Molecular Formula | C₂₈H₃₈N₁₂O₆S |
| Appearance | White to Off-White Solid |
| Melting Point | >205°C (dec.) |
| Molecular Weight | 670.74 |
| Storage | -20°C, Inert atmosphere |
| Solubility | Methanol (Slightly), Water (Slightly) |
| Category | Standards; Pharmaceutical/API Drug Impurities/Metabolites; |
| Applications | Abacavir Sulfate (Abacavir - In House Impurity) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
| References |