A105000 Chemical Structure

All Products are stable to be shipped at room temperature, unless otherwise specified.
Pack SizeQuantityPrice (USD)Sub Total
10mg
$ 70.000.0
50mg
$ 105.000.0
100mg
$ 140.000.0
5g
$ 240.000.0
Exact Weight Packaging
$ 145.000.0
Total$ 0.0
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A105000

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Product Description

Catalogue NumberA105000
Chemical NameAbacavir Sulfate
Synonyms(1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Sulfate; Ziagen; Abacavir - In House Impurity; Abacavir Impurities; Abacavir Intermediates
ImpurityAbacavir - In House Impurity
CAS Number188062-50-2
Alternate CAS #free base: 136470-78-5
Molecular FormulaC₂₈H₃₈N₁₂O₆S
AppearanceWhite to Off-White Solid
Melting Point>205°C (dec.)
Molecular Weight670.74
Storage-20°C, Inert atmosphere
SolubilityMethanol (Slightly), Water (Slightly)
Category Standards; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsAbacavir Sulfate (Abacavir - In House Impurity) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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