TRC | Details of CAS = 1346605-40-0, ChemicalName = trans-Abacavir-d4 Hydrochloride, synonym = (1R,4R)-rel-4-[2-Amino-6-[cyclopropyl-d4)amino]-9H-purin-9-yl]-2-cyclopentene-1-methanol Hydrochloride; Abacavir Stable Isotope, MolFormula = C₁₄H₁₅D₄ClN₆O

Catalogue number:	A104997
Chemical name:	trans-Abacavir-d4 Hydrochloride
Synonyms:	(1R,4R)-rel-4-[2-Amino-6-[cyclopropyl-d4)amino]-9H-purin-9-yl]-2-cyclopentene-1-methanol Hydrochloride; Abacavir Stable Isotope
Impurity:
CAS Number:	1346605-40-0
Possible CAS #:	NA
Molecular form.:	C₁₄H₁₅D₄ClN₆O
Appearance:	No Data Available
Melting Point:	No Data Available
Mol. Weight:	326.82
Storage:	No Data Available
Solubility:	No Data Available
Stability:	No Data Available
Category:	Inhibitors, Isotope Labelled Compounds, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point:	No Data Available
Applications:	trans-Abacavir-d4 Hydrochloride is deuterium labeled trans-Abacavir Dihydrochloride (A104995), which is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Dangerous Goods Info:	NA
References:	(1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)


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