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|Pack Size||Quantity||Price (USD)||Sub Total|
|Exact Weight Packaging||$ 75.00||0.0|
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|Chemical Name||trans-Abacavir Dihydrochloride|
|Alternate CAS #||(HCl 1:1): 267668-71-3; 783292-37-5-free base|
|Appearance||White to Light Brown Solid|
|Melting Point||>144°C (dec.)|
|Solubility||DMSO, Water (Slightly)|
|Category||Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;|
|Applications||trans-Abacavir Dihydrochloride is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.|