Abacavir
| Catalogue Number: | A104990 |
| Chemical Name: | Abacavir |
| Synonyms: | (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; (1S-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; 1592U89; ABC; Abacavir API; Abacavir Impurities |
| Impurity: | Abacavir API |
| CAS Number: | 136470-78-5 |
| Molecular Formula: | C₁₄H₁₈N₆O |
| Appearance: | Off-White Solid |
| Melting Point: | 94-97°C |
| Molecular Weight: | 286.33 |
| Storage: | Refrigerator |
| Solubility: | DMSO (Slightly, Heated), Methanol (Slightly) |
| Category: | Inhibitors, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals |
| Applications: | Abacavir (Abacavir API) is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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All Products are stable to be shipped at room temperature, unless otherwise specified. |
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| MSDS: | A104990.pdf |
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