Abacavir
| Catalogue number: | A104990 |
| Chemical name: | Abacavir |
| Synonyms: | (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; (1S-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; 1592U89; ABC; Abacavir API; Abacavir Impurities |
| Impurity: | Abacavir API |
| CAS Number: | 136470-78-5 |
| Possible CAS #: | NA |
| Molecular form.: | C₁₄H₁₈N₆O |
| Appearance: | Off-White Solid |
| Melting Point: | 94-97°C |
| Mol. Weight: | 286.33 |
| Storage: | Refrigerator |
| Solubility: | DMSO (Slightly, Heated), Methanol (Slightly) |
| Stability: | No Data Available |
| Category: | Inhibitors, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals |
| Boiling Point: | No Data Available |
| Applications: | Abacavir (Abacavir API) is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
| Dangerous Goods Info: | NA |
| References: |
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| Peer Review Product Citations: | |
| MSDS: | A104990.pdf |
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