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| Pack Size | Quantity | Price (USD) | Sub Total |
|---|---|---|---|
| 10mg | $ 80.00 | 0.0 | |
| 50mg | $ 110.00 | 0.0 | |
| mg100 | $ 145.00 | 0.0 | |
| 250mg | $ 180.00 | 0.0 | |
| 500mg | $ 205.00 | 0.0 | |
| 1g | $ 260.00 | 0.0 | |
| Exact Weight Packaging | $ 95.00 | 0.0 | |
| Total | $ 0.0 | ||
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A104990
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Product Description
| Catalogue Number | A104990 |
| Chemical Name | Abacavir |
| Synonyms | (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; |
| Impurity | Abacavir API |
| CAS Number | 136470-78-5 |
| Molecular Formula | C₁₄H₁₈N₆O |
| Appearance | Off-White to Pale Beige Solid |
| Melting Point | 94-97°C |
| Molecular Weight | 286.33 |
| Storage | 4°C |
| Solubility | DMSO (Slightly, Heated), Methanol (Slightly) |
| Category | Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| Applications | Abacavir (Abacavir API) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
| References |