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Pack Size Quantity Price (USD) Sub Total
1mg
$ 175.00 0.0
2mg
$ 325.00 0.0
5mg
$ 615.00 0.0
10mg
$ 1195.00 0.0
Exact Weight Packaging
$ 75.00 / Vial 0.0
Total $ 0.0
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Inventory Status : In Stock

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Product Description

Catalogue Number: A104985
Chemical Name: Abacavir 5’-β-D-Glucuronide Sodium Salt
Synonyms: [(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopenten-1-yl]methyl-β-D-Glucopyranosiduronic Acid Sodium Salt; Abacavir 5’-Glucuronide Sodium Salt
Alternate CAS #: 384329-76-4 free acid
Molecular Formula: C₂₀H₂₅N₆NaO₇
Appearance: Pale Beige Solid
Melting Point: >206°C (dec.)
Molecular Weight: 484.44
Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility: Methanol (Slightly), Water (Slightly)
Stability: Hygroscopic
Applications: Abacavir 5’-β-D-Glucuronide is a metabolite of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References
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