A104985 Chemical Structure

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Pack SizeQuantityPrice (USD)Sub Total
1mg
$ 215.000.0
2mg
$ 400.000.0
mg5
$ 745.000.0
10mg
$ 1450.000.0
Exact Weight Packaging
$ 95.000.0
Total$ 0.0
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A104985

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Product Description

Catalogue NumberA104985
Chemical NameAbacavir 5’-β-D-Glucuronide Sodium Salt
Synonyms[(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopenten-1-yl]methyl-β-D-Glucopyranosiduronic Acid Sodium Salt; Abacavir 5’-Glucuronide Sodium Salt
Alternate CAS #384329-76-4 free acid
Molecular FormulaC20H25N6NaO7
AppearancePale Beige Solid
Melting Point>206°C (dec.)
Molecular Weight484.44
StorageHygroscopic, -20°C Freezer, Under inert atmosphere
SolubilityMethanol (Slightly), Water (Slightly)
StabilityHygroscopic
Category Standards; Enzyme Activators and Inhibitors;
ApplicationsAbacavir 5’-β-D-Glucuronide is a metabolite of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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