Abacavir 5’-β-D-Glucuronide Sodium Salt

Catalogue number: A104985
Chemical name: Abacavir 5’-β-D-Glucuronide Sodium Salt
Synonyms: [(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopenten-1-yl]methyl-β-D-Glucopyranosiduronic Acid Sodium Salt; Abacavir 5’-Glucuronide Sodium Salt
Impurity:
CAS Number: NA
Possible CAS #: NA
Molecular form.: C₂₀H₂₅N₆NaO₇
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 484.44
Storage: -20°C Freezer, Under inert atmosphere
Solubility: No Data Available
Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: Abacavir 5’-β-D-Glucuronide is a metabolite of Abacavir (A105000). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Dangerous Goods Info: NA
References: PMID: 22267465
PMID: 18479171
Peer Review Product Citations:

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2mg $325.00
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10mg $1195.00
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Inventory Status:   In Stock



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