A101030 Chemical Structure

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25mg
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50mg
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A101030

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Product Description

Catalogue NumberA101030
Chemical NameA 37203
SynonymsLu 201640; 2-[[3-[4-[2-(1,1-Dimethylethyl)-6-(trifluoromethyl)-4-pyrimidinyl]-1-piperazinyl]propyl]thio]-4(3H)-pyrimidinone; 2-[[3-[4-[2-(1,1-Dimethylethyl)-6-(trifluoromethyl)-4-pyrimidinyl]-1-piperazinyl]propyl]thio]-4(1H)-pyrimidinone
CAS Number220519-06-2
Molecular FormulaC₂₀H₂₇F₃N₆OS
AppearanceOff-White Solid
Melting Point133-138°C
Molecular Weight456.53
Storage-20°C, Inert atmosphere
SolubilityDMSO (Slightly), Methanol (Slightly)
Category Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsA 37203 is a selective D3 receptor antagonist and intermediate in the synthesis of ABT 925 Fumerate (A112600), which is also a dopamine D3 receptor antagonist and used in the treatment of acute schizophrenia.
ReferencesRedden, L., et al.: J. Clin. Psychopharmacol, 31, 221 (2011); Basso, A.M., et al.: Neuropsychopharmacology, 30, 1257 (2005)