A101010 Chemical Structure

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Product Description

Catalogue NumberA101010
Chemical NameA350619 Hydrochloride
Synonyms3-[2-[(4-Chlorophenyl)thio]phenyl]-N-[4-(dimethylamino)butyl]-2-propenamide, , Hydrochloride;
CAS Number1217201-17-6
Molecular FormulaC₂₁H₂₆Cl₂N₂OS
Molecular Weight425.41
Category Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
ApplicationsA350619 Hydrochloride is an activator of guanylyl cyclase (sGC). It activates basal sGC and synergistically activates sGC in the presence of NO. Acting as an sGC stimulator, it may be more effective than PDE5 inhibitors in the treatment of ED.
ReferencesGur, S., et al.: Curr. Pharm. Des., 16, 1619 (2010); Nandhakumar, J., et al.: J. Neurol. Neurophysiol., 2, 1000110 (2011); Miller, L., et al.: Life Sci., 72, 1015 (2003);